Ribbon Synapses: Anchors away for a Fishy Tale
نویسنده
چکیده
Genetic screens in flies and worms have long been a powerful way of identifying proteins that regulate synaptic transmission. A recent study of ribbon synapses in the retina of zebrafish is an excellent example of how this approach can now be applied to a vertebrate species.
منابع مشابه
Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses.
Ribbon-type presynaptic active zones are a hallmark of excitatory retinal synapses, and the ribbon organelle is thought to serve as the organizing point of the presynaptic active zone. Imaging of exocytosis from isolated retinal neurons, however, has revealed ectopic release (i.e., release away from ribbons) in significant quantities. Here, we demonstrate in an in vitro mouse retinal slice prep...
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he ribbon complex of retinal photoreceptor synapses represents a specialization of the cytomatrix at the active zone (CAZ) present at conventional synapses. In mice deficient for the CAZ protein Bassoon, ribbons are not anchored to the presynaptic membrane but float freely in the cytoplasm. Exploiting this phenotype, we dissected the molecular structure of the photoreceptor ribbon complex. Iden...
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ورودعنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005